Cancer (medical term:
malignant neoplasm) is a class of
diseases in which a group of
cells display uncontrolled growth (
division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes
metastasis (spread to other locations in the body via lymph or blood). These three malignant properties of cancers differentiate them from
benign tumors, which are self-limited, do not invade or metastasize. Most cancers form a
tumor but some, like
leukemia, do not. The branch of medicine concerned with the study, diagnosis, treatment, and prevention of cancer is
oncology.Cancer may affect people at all ages, even
fetuses, but the risk for most varieties increases with age. Cancer causes about 13% of
all deaths. According to the
American Cancer Society, 7.6 million people died from cancer in the world during 2007. Cancers can affect all animals.Nearly all cancers are caused by abnormalities in the
genetic material of the
transformed cells[
citation needed]. These abnormalities may be due to the effects of
carcinogens, such as
tobacco smoke,
radiation,
chemicals, or
infectious agents. Other cancer-promoting genetic abnormalities may be randomly acquired through errors in
DNA replication, or are
inherited, and thus present in all cells from birth. The
heritability of cancers are usually affected by complex interactions between carcinogens and the host's
genome. New aspects of the genetics of cancer pathogenesis, such as
DNA methylation, and
microRNAs are increasingly recognized as important.Genetic abnormalities found in cancer typically affect two general classes of genes. Cancer-promoting
oncogenes are typically activated in cancer cells, giving those cells new properties, such as hyperactive growth and division, protection against
programmed cell death, loss of respect for normal tissue boundaries, and the ability to become established in diverse tissue environments.
Tumor suppressor genes are then inactivated in cancer cells, resulting in the loss of normal functions in those cells, such as accurate DNA replication, control over the
cell cycle, orientation and adhesion within tissues, and interaction with protective cells of the
immune system.
Cancer can be treated by
surgery,
chemotherapy,
radiation therapy,
immunotherapy,
monoclonal antibody therapy or other methods. The choice of therapy depends upon the location and grade of the tumor and the
stage of the disease, as well as the general state of the patient (
performance status). A number of
experimental cancer treatments are also under development.Complete removal of the cancer without damage to the rest of the body is the goal of treatment. Sometimes this can be accomplished by surgery, but the propensity of cancers to invade adjacent tissue or to spread to distant sites by microscopic metastasis often limits its effectiveness. The effectiveness of chemotherapy is often limited by toxicity to other tissues in the body. Radiation can also cause damage to normal tissue.Because "cancer" refers to a class of diseases, it is unlikely that there will ever be a single "
cure for cancer" any more than there will be a single treatment for all
infectious diseases.
SurgeryIn theory, non-
hematological cancers can be cured if entirely removed by
surgery, but this is not always possible. When the cancer has
metastasized to other sites in the body prior to surgery, complete surgical excision is usually impossible. In the
Halstedian model of cancer progression,
tumors grow locally, then sp
read to the lymph nodes, then to the rest of the body. This has given rise to the popularity of local-only treatments such as surgery for small cancers. Even small localized tumors are increasingly recognized as possessing metastatic potential.Examples of surgical procedures for cancer include
mastectomy for breast cancer and
prostatectomy for prostate cancer. The goal of the surgery can be either the removal of only the tumor, or the entire organ. A single cancer cell is invisible to the naked eye but can regrow into a new tumor, a process called recurrence. For this reason, the
pathologist will examine the surgical specimen to determine if a margin of healthy tissue is present, thus decreasing the chance that microscopic cancer cells are left in the patient.In addition to removal of the primary tumor, surgery is often necessary for
staging, e.g. determining the extent of the disease and whether it has
metastasized to regional
lymph nodes. Staging is a major determinant of
prognosis and of the need for
adjuvant therapy.Occasionally, surgery is necessary to control symptoms, such as
spinal cord compression or
bowel obstruction. This is referred to as
palliative treatment.
Cancer (medical term: malignant neoplasm) is a class of diseases in which a group of cells display uncontrolled growth (division beyond the normal limits), invasion (intrusion on and destruction of adjacent tissues), and sometimes metastasis (spread to other locations in the body via lymph or blood). These three malignant properties of cancers differentiate them from benign tumors, which are self-limited, do not invade or metastasize. Most cancers form a tumor but some, like leukemia, do not. The branch of medicine concerned with the study, diagnosis, treatment, and prevention of cancer is oncology.Cancer may affect people at all ages, even fetuses, but the risk for most varieties increases with age. Cancer causes about 13% of all deaths. According to the American Cancer Society, 7.6 million people died from cancer in the world during 2007. Cancers can affect all animals.Nearly all cancers are caused by abnormalities in the genetic material of the transformed cells[citation needed]. These abnormalities may be due to the effects of carcinogens, such as tobacco smoke, radiation, chemicals, or infectious agents. Other cancer-promoting genetic abnormalities may be randomly acquired through errors in DNA replication, or are inherited, and thus present in all cells from birth. The heritability of cancers are usually affected by complex interactions between carcinogens and the host's genome. New aspects of the genetics of cancer pathogenesis, such as DNA methylation, and microRNAs are increasingly recognized as important.Genetic abnormalities found in cancer typically affect two general classes of genes. Cancer-promoting oncogenes are typically activated in cancer cells, giving those cells new properties, such as hyperactive growth and division, protection against programmed cell death, loss of respect for normal tissue boundaries, and the ability to become established in diverse tissue environments. Tumor suppressor genes are then inactivated in cancer cells, resulting in the loss of normal functions in those cells, such as accurate DNA replication, control over the cell cycle, orientation and adhesion within tissues, and interaction with protective cells of the immune system.
Cancer can be treated by surgery, chemotherapy, radiation therapy, immunotherapy, monoclonal antibody therapy or other methods. The choice of therapy depends upon the location and grade of the tumor and the stage of the disease, as well as the general state of the patient (performance status). A number of experimental cancer treatments are also under development.Complete removal of the cancer without damage to the rest of the body is the goal of treatment. Sometimes this can be accomplished by surgery, but the propensity of cancers to invade adjacent tissue or to spread to distant sites by microscopic metastasis often limits its effectiveness. The effectiveness of chemotherapy is often limited by toxicity to other tissues in the body. Radiation can also cause damage to normal tissue.Because "cancer" refers to a class of diseases, it is unlikely that there will ever be a single "cure for cancer" any more than there will be a single treatment for all infectious diseases.SurgeryIn theory, non-hematological cancers can be cured if entirely removed by surgery, but this is not always possible. When the cancer has metastasized to other sites in the body prior to surgery, complete surgical excision is usually impossible. In the Halstedian model of cancer progression,
tumors grow locally, then spread to the lymph nodes, then to the rest of the body. This has given rise to the popularity of local-only treatments such as surgery for small cancers. Even small localized tumors are increasingly recognized as possessing metastatic potential.Examples of surgical procedures for cancer include mastectomy for breast cancer and prostatectomy for prostate cancer. The goal of the surgery can be either the removal of only the tumor, or the entire organ. A single cancer cell is invisible to the naked eye but can regrow into a new tumor, a process called recurrence. For this reason, the pathologist will examine the surgical specimen to determine if a margin of healthy tissue is present, thus decreasing the chance that microscopic cancer cells are left in the patient.In addition to removal of the primary tumor, surgery is often necessary for staging, e.g. determining the extent of the disease and whether it has metastasized to regional lymph nodes. Staging is a major determinant of prognosis and of the need for adjuvant therapy.Occasionally, surgery is necessary to control symptoms, such as spinal cord compression or bowel obstruction. This is referred to as palliative treatment.
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